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WP lead: Charline Warembourg, INSERM
WP Co-lead: Liesbeth Duijts, EMC
Work Package 1 sets out to assess the health effects associated with exposure to EDC mixtures across different stages of human life. Through rigorous evaluation, WP1 aims to uncover the intricate relationship between EDC mixtures and long-term disease development. Central to this investigation is the examination of immunological markers, providing valuable insights into the underlying mechanisms driving these associations. By focusing on a diverse range of life stages, WP1 endeavours to shed light on the varying susceptibilities and impacts of EDC mixtures on human health.
WP lead: Beate Escher, UFZ
Work Package 2 is dedicated to the identification of chemical mixtures of concerns for endocrine disruption and immunotoxicity-related adverse outcomes. Employing a multifaceted approach, WP2 utilizes cutting-edge in silico, in vitro, and alternative toxicity tools to comprehensively assess the potential effects of these chemical mixtures.
WP lead: Anne Schumacher, UFZ
Work Package 3 focuses on analysing the immunotoxic and immunomodulatory potential of selected EDCs and mixtures. Through the utilization of cellular assays, WP3 investigates the impact of these substances on various aspects of immune cell biology, including population dynamics, functionality, differentiation, maturation, and plasticity.
WP lead: Yvonne Kohl, Fraunhofer
Work Package 4 is dedicated to assessing the impact of EDCs and mixtures on physiological barriers, target organs, and immune cell-organ interactions. Employing human-relevant in vitro and alternative models, WP4 investigates how EDC exposure influences the integrity and function of physiological barriers.
WP lead: Janine Felix, EMC
Work Package 5 delves into the intricate relationship between immune-mediated effects of EDCs and human health outcomes. Through comprehensive analysis, WP5 investigates the associations of EDC exposure with inflammatory immune markers, shedding light on the underlying biological pathways involved.
WP lead: Roel Vermeulen, UU
Work Package 6 serves as a crucial nexus for deriving causal associations between EDC exposure and health outcomes. Drawing upon the comprehensive findings from WP3, WP4, and WP5, WP6 synthesizes information to establish causal inference and provide integrated evidence for informing risk assessment policies and approaches. By elucidating the pathways linking EDC exposure to adverse health outcomes, WP6 facilitates the translation of research findings into actionable insights for policymakers, regulatory bodies, and public health practitioners.
WP lead: Katharina Krischak, EIBIR
Work Package 7 is tasked with coordinating the dissemination activities of the ENDOMIX project to maximize visibility and engage a broad range of stakeholders. Through strategic planning and implementation, WP7 ensures that the project’s findings and outcomes reach relevant audiences, including policymakers, regulatory bodies, scientific communities, and the general public. Additionally, WP7 establishes a framework for identifying and capitalizing on exploitation opportunities, facilitating the uptake and utilization of project results. Moreover, WP7 plays a vital role in managing intellectual property (IP) to safeguard the project’s innovations and support their effective exploitation.
WP lead: Ana Zenclussen, UFZ
Work Package 8 is dedicated to ensuring the comprehensive management of the ENDOMIX project across legal, contractual, administrative, financial, and ethical domains. With a focus on effective governance and decision-making mechanisms, WP8 oversees project coordination, facilitating seamless communication and collaboration among project partners. Furthermore, WP8 is responsible for reporting to the European Commission (EC), ensuring compliance with regulatory requirements and guidelines.
WP lead: Ana Zenclussen, UFZ
Work Package 9 coordinates, organises and executes the activities of ENDOMIX within the ENKORE cluster, establishing a strong foundation for the collaborative efforts within the cluster and ensuring efficient coordination and implementation of the joint activities across the various projects involved.
WP lead: Ana Zenclussen, UFZ
Work Package 10 sets out the necessary ethics requirements for the project and ensures the compliance of ENDOMIX with all relevant ethics rules and regulations.